Classification and monomer-by-monomer annotation of human alpha satellite Higher-Order Repeats and pericentromeric monomer layers in human genome assembly draft 20200611.
Annotation tables are shown at: How_to_read_AS_annotation
Based on the phylogenetic and genomic analysis of alpha satellites in hg38 genome assembly. Alpha satellite monomer sequences were established as profiles in HMMER to create monomer-by-monomer annotation track for UCSC Genome Browser.
Unpublished data, please do not share outside the T2T consortium!
Uralsky, L. I.; Shepelev, V. A.; Alexandrov, A. A.; Yurov, Y. B.; Rogaev, E. I.; Alexandrov, I. A. Classification and Monomer-by-Monomer Annotation Dataset of Suprachromosomal Family 1 Alpha Satellite Higher-Order Repeats in Hg38 Human Genome Assembly. Data Brief 2019, 24, 103708. https://doi.org/10.1016/j.dib.2019.103708.
Shepelev, V. A.; Uralsky, L. I.; Alexandrov, A. A.; Yurov, Y. B.; Rogaev, E. I.; Alexandrov, I. A. Annotation of Suprachromosomal Families Reveals Uncommon Types of Alpha Satellite Organization in Pericentromeric Regions of Hg38 Human Genome Assembly. Genom Data 2015, 5, 139–146. https://doi.org/10.1016/j.gdata.2015.05.035.
Shepelev, V. A.; Alexandrov, A. A.; Yurov, Y. B.; Alexandrov, I. A. The Evolutionary Origin of Man Can Be Traced in the Layers of Defunct Ancestral Alpha Satellites Flanking the Active Centromeres of Human Chromosomes. PLoS Genet. 2009, 5 (9), e1000641. https://doi.org/10.1371/journal.pgen.1000641.
Contact Lev I. Uralsky <uralsky@rogaevlab.ru>
Contact Ivan A. Alexandrov <ivanalx@hotmail.com>
Lev I. Uralsky (Vavilov Institute of General Genetics RAS)
Valery A. Shepelev (Vavilov Institute of General Genetics RAS)
Ivan A. Alexandrov (Vavilov Institute of General Genetics RAS)